Aldehyde Oxidase (AO)
Aldehyde Oxidase; AO
Aldehyde Oxidase is a soluble cytoplasmic molybdenum-containing enzyme that is mainly involved in the biotransformation of various drugs and xenobiotics. Aldehyde Oxidase has four isoforms (AOX1, AOX3, AOX3L1, and AOX4). Aldehyde Oxidase is mainly expressed by the liver, but is distributed widely in the lungs, kidneys, brain, and skin. Aldehyde Oxidase catalyzes oxidation and reduction reactions, among which the oxidation of aldehydes, nitro/nitroso compounds or N-heterocycles are more common. Aldehyde Oxidase affects drug metabolism, impacts drug interactions, and generates potential toxic metabolites. Aldehyde Oxidase could lead to liver damage (such as NAFLD), renal toxicity and amyotrophic lateral sclerosis (ALS)[1][2].
References:
- [1]. Manevski N, et al., Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery. J Med Chem. 2019 Dec 26;62(24):10955-10994. [Content Brief]
- [2]. Pryde DC, et al., Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem. 2010 Dec 23;53(24):8441-60. [Content Brief]
Aldehyde Oxidase (AO) Isoform Specific Products
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Aldehyde Oxidase (AO) Related Products (4)
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Aldehyde Oxidase (AO) Isoform Comparison
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Quinacrine
0 ImagesQuinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm).
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ANA-975
0 ImagesCat. No.: HY-19844CAS No.: 847453-47-8ANA975, 5-amino-3-β -D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one derivative, is an oral prodrug of the TLR-7 agonist Isatoribine (HY-13655A). ANA975 is converted to Isatoribine via a combined mechanism of hydrolysis by esterases and oxidation by aldehyde oxidase. ANA975 can be used in the research of hepatitis C virus infection.
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Phenanthridine
0 ImagesCat. No.: HY-W142745CAS No.: 229-87-8Phenanthridine is an aldehyde oxidase 1 (AOX1) substrate, with oxidation by hAOX1 yielding phenanthridone when molecular oxygen, ferricyanide, or dichlorophenolindophenol serves as electron acceptor.
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Aox1 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS17631Aox1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aox1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
